姓名：田丽春

职称：高级实验师

岗位类别：测试服务

所在实验室：北京中医药研究院机能与形态测试平台

工作邮箱：202006001@bucm.edu.cn

教育经历：2008.09-2011.07 中山大学 基础医学专业 理学博士学位

研究专长：擅长生化分析仪、凝血分析仪、血液分析仪的样品测试和常见故障处理

管辖仪器设备名称：生化分析仪、凝血分析仪、血液分析仪、血流变仪

研究项目：国家自然科学基金青年项目，腺相关病毒介导拮抗型IL-4突变体基因治疗小鼠哮喘的初步研究 (81300016)，2014/01-2016/12，主持, 已结题

论文：

1）: Zhang Y, Zhen J, Sun Y, Li Y, Zhou Y, Li C, Tian L. Profiles of Circulating Exosomal Mirna in Patients with SAPHO Patients by High-Throughput Sequencing. Comb Chem High Throughput Screen. 2024 May 14. doi: 10.2174/0113862073289083240425114858. Epub ahead of print. PMID: 38752639.

2）: Wang H, Feng Y, Zhang Y, Wang T, Xu H, Zhi Y, Feng Y, Tian L, Yuan K. Siglec10-An immunosuppressor and negative predictor of survival prognosis in gliomas. Front Genet. 2022 Nov 16;13:873655. doi: 10.3389/fgene.2022.873655. PMID: 36468012; PMCID: PMC9709431.

3）: Xu H, Feng Y, Kong W, Wang H, Feng Y, Zhen J, Tian L, Yuan K. High Expression Levels of SIGLEC9 Indicate Poor Outcomes of Glioma and Correlate With Immune Cell Infiltration. Front Oncol. 2022 Jun 9;12:878849. doi: 10.3389/fonc.2022.878849. PMID: 35756603; PMCID: PMC9218569.

4）: Wang H, Liu C, Xu H, Zhang Y, Gao P, Geng S, Kong W, Zhi Y, Yuan K, Tian L. The Association between Serum Anion Gap and All-Cause Mortality in Cerebral Infarction Patients after Treatment with rtPA: A Retrospective Analysis. Dis Markers. 2022 May 12;2022:1931818. doi: 10.1155/2022/1931818. PMID: 35601742; PMCID: PMC9119778.

5）: Tu C, Xu Z, Tian L, Yu Z, Wang T, Guo Z, Zhang J, Wang T. Multi-Omics Integration to Reveal the Mechanism of Hepatotoxicity Induced by Dictamnine. Front Cell Dev Biol. 2021 Sep 14;9:700120. doi: 10.3389/fcell.2021.700120. PMID: 34595163; PMCID: PMC8476863.

6）: Xu Z, Kang Q, Yu Z, Tian L, Zhang J, Wang T. Research on the Species Difference of the Hepatotoxicity of Medicine Based on Transcriptome. Front Pharmacol. 2021 Apr 23;12:647084. doi: 10.3389/fphar.2021.647084. PMID: 33995060; PMCID: PMC8115263.

7）:  Zhang Y, Wang Y, Yang K, Tian L, Fu X, Wang Y, Sun Y, Jiang Q, Lu W, Wang J. BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. PLoS One. 2014 Dec 2;9(12):e112695. doi: 10.1371/journal.pone.0112695. PMID: 25461595; PMCID: PMC4251900.

8）:  Wang J, Chen Y, Lin C, Jia J, Tian L, Yang K, Zhao L, Lai N, Jiang Q, Sun Y, Zhong N, Ran P, Lu W. Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C364-73. doi: 10.1152/ajpcell.00048.2013. Epub 2013 Dec 11. PMID: 24336649; PMCID: PMC3919980.

9）: Zhang Y, Lu W, Yang K, Xu L, Lai N, Tian L, Jiang Q, Duan X, Chen M, Wang J. Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca(2+) entry, and basal [Ca(2+)]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2013 May 1;304(9):C833-43. doi: 10.1152/ajpcell.00036.2012. Epub 2013 Feb 27. PMID: 23447035; PMCID: PMC3651608.

10）: Wang J, Lu W, Wang W, Zhang N, Wu H, Liu C, Chen X, Chen Y, Chen Y, Jiang Q, Xu L, Tian L, Ran P, Zhong N. Promising therapeutic effects of sodium tanshinone IIA sulfonate towards pulmonary arterial hypertension in patients. J Thorac Dis. 2013 Apr;5(2):169-72. doi: 10.3978/j.issn.2072-1439.2013.02.04. PMID: 23585945; PMCID: PMC3621926.

11）: Tian L, Lei B, Shao J, Wei L, Kijlstra A, Yang P. AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis. PLoS One. 2012;7(6):e37995. doi: 10.1371/journal.pone.0037995. Epub 2012 Jun 7. PMID: 22685550; PMCID: PMC3369876.

12）: Shao J, Tian L, Lei B, Wei L, Yang Y, Kijlstra A, Yang P. AAV2-mediated subretinal gene transfer of mIL-27p28 attenuates experimental autoimmune uveoretinitis in mice. PLoS One. 2012;7(5):e37773. doi: 10.1371/journal.pone.0037773. Epub 2012 May 22. PMID: 22629453; PMCID: PMC3358269.

13）: Tian L, Yang P, Lei B, Shao J, Wang C, Xiang Q, Wei L, Peng Z, Kijlstra A. AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice. PLoS One. 2011;6(5):e19542. doi: 10.1371/journal.pone.0019542. Epub 2011 May 17. PMID: 21611186; PMCID: PMC3096632.

荣誉奖励：中华医学科技奖一等奖，两种重要致盲眼病---Behcet病，Vogt-小柳原田综合征的发病机制，诊断和治疗（201201131），排名十五